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Gastro Retentive Innovative Device (GRID™)

The GRID™ system provides predictive, reliable, sequential and combinatorial mechanisms to overcome anatomical- physiological barriers which otherwise challenge controlled release administration of drugs with narrow window of absorption or drugs intended to have local action.

The combination of mechanisms helps to retain the product in stomach for prolonged period of time which ensures success of once a day dosage form of such products.

The proprietary formulation contains controlled release core and multiple functional coats which include gas generating coat and expandable coat. The expandable coat absorbs gastric fluid and swells about 8 to 10 times its original size which ensures its retention in stomach even after gastric emptying for 6 to 8 hours. This versatile device can also be modified for gradient release profile by doing minor modifications.

The technology is commercially tested in Baclofen GRS Capsules, marketed in India by Sun Pharmaceutical Laboratories Ltd with the brand name Liofen® XL.

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The GRID™ system provides predictive, reliable, sequential and combinatorial mechanisms to overcome anatomical- physiological barriers which otherwise challenge controlled release administration of drugs with narrow window of absorption or drugs intended to have local action.

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